ProRank+ - A Method for Detecting Protein Complexes in Protein Interaction Networks
نویسندگان
چکیده
The course of developing effective medical treatments is typically based on the identification of diseasetriggering protein complexes. In this paper, we present ProRank+, an effective method for detecting protein complexes in protein interaction networks. By assuming that complexes may overlap, the method uses a ranking algorithm to order proteins based on their importance in the network. In addition, a novel merging procedure is introduced to refine the predicted complexes in terms of their members. The experimental studies and results showed that ProRank+ outperforms several state-of-the-art methods in terms of the number of correctly-detected protein complexes using numerous quality measures.
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